Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session F08: Physics of Proteins II: Structure & Dynamics of Proteins
8:00 AM–11:00 AM,
Tuesday, March 7, 2023
Room: Room 131
Sponsoring
Unit:
DBIO
Chair: Aihua Xie, Oklahoma State U
Abstract: F08.00009 : Interfacial charge transfer of amyloid-β proteins with graphene examined using Raman spectroscopy*
10:24 AM–10:36 AM
Presenter:
Wujoon Cha
(Sungkyunkwan University)
Authors:
Wujoon Cha
(Sungkyunkwan University)
Chaejeong Heo
(Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University)
Sang Hyub Lee
(Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University)
Seok Joon Yoon
(Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University)
Byeong Wook Cho
(Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University)
Taewoo Ha
(Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University)
Young Hee Lee
(Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University)
In this work, we investigate the electronic states of Aβ proteins at different fibrillization stages. We achieve this by monitoring the interfacial charge transfer between Aβ proteins and monolayer graphene using Raman spectroscopy. Graphene, an atomically thin semimetal, reacts sensitively to charge-transfer-induced doping and the shifts in the carrier concentrations and in the Fermi levels can be distinguished from the characteristic Raman bands in graphene (G and 2D). In particular, we found that graphene was p-doped by monomers while n-doped by fibrils, indicating that the electronic energy levels of Aβs shift as they aggregate. This charge-transfer polarity between the monomer and the fibril states provides critical insights into the electronic properties of Aβs that are essential to identifying the onset of neurotoxic Aβ fibril formation and developing a rapid, label-free diagnosis protocol based on two-dimensional materials.
*This work was supported by the Institute for Basic Science of Korea (IBS-R011-D1)
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