Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session F04: Beyond Linear: Structure, Dynamics, Response and Unique Properties of Topological Polymers I
8:00 AM–10:48 AM,
Tuesday, March 7, 2023
Room: Room 127
Sponsoring
Unit:
DPOLY
Chair: Ting Ge, University of South Carolina
Abstract: F04.00006 : AFM investigation of Topological and Physical Properties of Kinetoplast DNA*
9:48 AM–10:00 AM
Presenter:
Maria Maalouf
(California State University, Long Beach)
Authors:
Maria Maalouf
(California State University, Long Beach)
Ryan Blair
(California State University, Long Beach)
Alexander R Klotz
(California State University, Long Beach)
Collaboration:
CSULB-OSU Partnership for Research and Education in Materials (PREM)
physics and their topology, particularly as an example of mechanically interlocked molecular rings (polycatenanes). The mechanisms of stiffness and flexibility within topologically
interlocked molecules are not fully understood. In this study, linked-ring structures are extracted from the kinetoplasts by dissolving the networks using restriction enzymes and scanned with an Atomic Force Microscope (AFM). The AFM images are analyzed to measure the persistence length of the DNA polycatenanes by mapping them onto the wormlike chain model. Here, we report on the properties of kinetoplast-derived polycatenanes, including apparent branched structures that form as well as their persistence length. Additionally, we discuss the results of a mathematical model that establishes that kinetoplast DNA can adopt a crossing-number-minimizing conformation.
*NSF MRI: Acquisition of an Atomic Force Microscopy-Infrared Spectroscopy (AFM-IR) System for Multidisciplinary Research and Education ( 2117629)NSF PREM: Cal. State Univ. Long Beach and Ohio State University Partnership for Education and Research in Hard and Soft Materials (2122199)NSF RUI: Materials Physics with Kinetoplast DNA (2105113)NSF Mentored Excellence Toward Research and Industry Careers (1833753)
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