Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session D11: Physics of Neural Systems II
3:00 PM–6:00 PM,
Monday, March 6, 2023
Room: Room 203
Sponsoring
Unit:
DBIO
Chair: Tiberiu Tesileanu, Flatiron Institute
Abstract: D11.00010 : MiV-Simulator: A computational framework to simulate exact scale in-vitro neuronal networks*
5:36 PM–5:48 PM
Presenter:
Gaurav Upadhyay
(University of Illinois at Urbana-Champaign)
Authors:
Gaurav Upadhyay
(University of Illinois at Urbana-Champaign)
Seung Hyun Kim
(University of Illinois at Urbana-Champaign)
Frithjof Gressmann
(University of illinois at Urbana-Champaign)
Ivan Raikov
(Stanford University)
Zhi Dou
(University of Illinois at Urbana-Champai)
Xiaotian Zhang
(University of Illinois at Urbana-Champai)
Ivan Soltesz
(Stanford University)
Lawrence Rauchwerger
(University of Illinois ar Urbana-Champaign)
Mattia Gazzola
(University of Illinois at Urbana-Champaign)
Importantly, our framework supports the simulation of local field potentials (LFP), optogenetic stimulation, and other common paradigms of experimental neuroscience. The framework's ability to simulate signals at different spatial scales allows not only to closely mimic in vitro experiments, but also the concurrent observation and analysis of all components of the neural dynamical system. We validate our approach by comparing firing rate distributions of simulated networks with those obtained from multi-electrode array recordings across a variety of neuron cultures and demonstrate that key features can be recapitulated in silico.
*NSF Expedition 'Mind in Vitro' Award #IIS–2123781(MG)
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