Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session Y05: Biomaterials and Nanotechnology II
8:00 AM–11:00 AM,
Friday, March 18, 2022
Room: McCormick Place W-178A
Sponsoring
Units:
DBIO DPOLY
Chair: Lydia Kisley, Case Western Reserve University
Abstract: Y05.00001 : 3D Porous Liquid Crystal Elastomer Scaffolds as Cell Supports for Long-term Tissue Cultures*
8:00 AM–8:12 AM
Presenter:
Senay Ustunel
(Kent State University)
Authors:
Senay Ustunel
(Kent State University)
Marianne E Prévôt
(Kent State University)
Grace Rohaley
(Kent State University)
Robert J Clements
(Kent State University)
Elda Hegmann
(Kent State University)
The human body is composed of 200 different types of cells, and each has distinct properties requiring scaffolds to have cell-matched mechanical properties and pore sizes. I will present mechanically tunable, biocompatible, and biodegradable liquid crystal elastomers and elastomers with a porous structure that have been made to specifically address the needs of two distinctive cell lines. Cellulose nanocrystals were used as biocompatible additives to tune the mechanical properties and salt leaching method used to engineer desired porous structure and how we created scaffolds with diverse elasticities and their effect on cell growth by using two distinct cell lines. I will finish by presenting how our 3D-LCE scaffolds provide a unique environment to longitudinally study spatial neuronal functions, not possible in conventional culture environments, and how we use LC anisotropy to guide directionality and alignment of cells.
*NSF, US Department of Energy, KSU, ALS, BNL
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