Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session R12: Macromolecular Phase Separation IV
8:00 AM–10:24 AM,
Thursday, March 18, 2021
Sponsoring
Unit:
DBIO
Chair: Ned Wingreen, Princeton University; Patrick McCall, Max Planck Institute for the Physics of Complex Systems
Abstract: R12.00006 : Stochastic dynamics of single molecules across phase boundaries
9:00 AM–9:12 AM
Live
Presenter:
Stefano Bo
(Max Planck Institute for the Physics of Complex Systems)
Authors:
Stefano Bo
(Max Planck Institute for the Physics of Complex Systems)
Lars Hubatsch
(Max Planck Institute for the Physics of Complex Systems)
Christoph Weber
(Max Planck Institute for the Physics of Complex Systems)
Frank Julicher
(Max Planck Institute for the Physics of Complex Systems)
Starting from a continuum theory of macroscopic phase separation we derive a Langevin equation for molecular trajectories that takes into account thermal fluctuations.
We find that a molecule experiences an effective potential, which has a steep gradient at phase boundaries. We obtain the position-dependent diffusion coefficient and the drift velocity, which is caused by concentration fluxes.
We discuss how the physics of phase separation affects the statistics of molecular trajectories. We show that our approach can be used to infer key phase separation parameters from the statistics of single-molecule trajectories.
Finally, we show that, when the system is not at equilibrium, detailed balance is broken at the level of molecular trajectories. Such trajectories can thus be used to characterize non-equilibrium features of intracellular condensates.
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