Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session B12: Macromolecular Phase Separation II
11:30 AM–2:30 PM,
Monday, March 15, 2021
Sponsoring
Units:
DBIO DPOLY GSNP DSOFT
Chair: Daphne Klotsa, Univ of NC - Chapel Hill; Yaojun Zhang, Princeton University
Abstract: B12.00006 : BIAPSS - comprehensive bioinformatic analysis of liquid-liquid phase separating sequences
12:54 PM–1:06 PM
Live
Presenter:
Aleksandra Elzbieta Badaczewska-Dawid
(Iowa State University)
Authors:
Aleksandra Elzbieta Badaczewska-Dawid
(Iowa State University)
Davit Potoyan
(Iowa State University)
To reveal common motifs of protein sequences that promote PS, we have carried out large-scale statistical analysis of phase separating protein deposited in the LLPS databases. For each motif, the most significant interactions have been identified (e.g. charge, hydropathy, polarity, pi-stacking). The bioinformatic analysis provides us with the knowledge about sequence conservation, secondary structure preferences, solvent accessibility, contacts, charge decoration, AA composition, and short linear motifs detection.
The recently developed by us BIAPSS tool is a publically accessible repository that may be used by both experimentalists for designing controlled mutations and for computationally-oriented scientists for developing new modeling tools.
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700