Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session A13: Biomaterials I
8:00 AM–11:00 AM,
Monday, March 15, 2021
Sponsoring
Unit:
DBIO
Chair: Pupa Gilbert, University of Wisconsin - Madison
Abstract: A13.00007 : Microfluidics & Algorithm for Comprehensive Small Volume Blood Diagnostics via Rapid Solidification of μL Drops into Homogeneous Thin Film Solid Films and XRF*
9:36 AM–9:48 AM
Live
Presenter:
Thilina Balasooriya
(Physics and Eyring Materials Center, Arizona State University)
Authors:
Thilina Balasooriya
(Physics and Eyring Materials Center, Arizona State University)
Wesley Peng
(Physics and Eyring Materials Center, Arizona State University)
Nikhil Suresh
(Physics and Eyring Materials Center, Arizona State University)
Aashi R Gurijala
(Physics and Eyring Materials Center, Arizona State University)
Mohammed Sahal
(SiO2 Innovates, LLC)
Eric Culbertson
(Physics and Eyring Materials Center, Arizona State University)
Robert J Culbertson
(Physics and Eyring Materials Center, Arizona State University)
Nicole Herbots
(Physics and Eyring Materials Center, Arizona State University)
Using microscopy, Ion Beam Analysis, and X-Ray Fluorescence (XRF), the present work studies blood drop microfluidics and rapid blood solidification. The hyper-hydrophilic coating, HemaDrop™, solidifies 10 µL-sized blood drops into Homogeneous Thin Solid Films (HTSFs). A new blood collection and solidification device, InnovaStrip™ [1], allows HTSFs to be analyzed via solid-state techniques for electrolytes and metals composition to ± 10%.
To address issues in XRF automated software, including background fit errors, Fast Accurate Blood Analysis (FABA), a new XRF algorithm specific to blood analysis, is implemented in a mobile app, Fast Hand-held Analysis for XRF. FABA makes BD portable when paired with Hand-Held XRF. It allows for data conversion from atomic % composition into mg/dL using built-in calibration HTSFs, integrated into the InnovaStrip™ design. FABA yields comprehensive BD using μLs of blood with accuracy and reproducibility to ± 10%.
[1] Herbots et al. Int. US. Pat. Pend (2020).
*SiO2 Innovates, LLC
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