Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session U27: Population Dynamics in Antibiotics and Time-Varying Environments
2:30 PM–5:30 PM,
Thursday, March 5, 2020
Sponsoring Units: DBIO GSNP
Chair: Arvind Murugan, University of Chicago
Abstract: U27.00002 : The role of drug kinetics on the evolution of resistance.
Alison Lynn Hill
With this in mind, we analyze the effect of dosing intervals on the establishment of drug resistance due to mutants existing prior to treatment (pre-existing) and those that are produced during treatment (rescue) in the presence of time-dependent drug profiles.
We find that there exists an initial time-frame after treatment initiation that has the most influence on the establishment probability of the drug resistant strain. Depending upon the nature of the drug kinetics during this time as well as infection parameters, increasing the dosing interval might be better or worse for the establishment of resistance. Our results suggest that drug kinetics affect selection and competition in the system in a complicated manner and should be factored in while designing new treatment strategies.
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