Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session M71: Poster Session III (11:15am - 2:15pm)
Wednesday, March 4, 2020
Room: Exhibit Hall C/D
Abstract: M71.00303 : Effects of Stochasticity in Biological Oscillators
(University of Chicago)
Many studies concur that motifs with positive and negative feedback are most robust to variations in the deterministic limit [1, 2], and in the stochastic regime [3, 4]. However, there is no mechanistic understanding for predicting the performance of different topologies.
Our findings suggest that deterministic amplitude, along with the distribution of angular velocities along the phase-space orbit of dynamical variables can lead to a mechanistic understanding of this trade-off. Regulation mechanisms and tuning of interaction strengths play a pivotal role in this optimization.
 Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE Jr, Science, 2008, Jul 4.
 Zhengda Li, Shixuan Liu, Qiong Yang, Cell Systems, Vol 5, Issue 1, 26 July 2017.
 Woods ML, Leon M, Perez-Carrasco R, Barnes CP, ACS Synth. Biol., 2016, 5(6), pp 459-470
 Vilar JMG, Kueh HY, Barkai N, Leibler S, Proc Natl Acad Sci USA. 2002 Apr 30; 99(9):5988-5992
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700