Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session S65: Physics of Genome Organization II
11:15 AM–2:15 PM,
Thursday, March 7, 2019
BCEC
Room: 260
Sponsoring
Units:
DBIO DPOLY GSNP
Chair: Alexandre Morozov, Rutgers Univ
Abstract: S65.00013 : How nucleoid associated proteins stabilize supercoiled DNA
2:03 PM–2:15 PM
Presenter:
Katelyn Dahlke
(University of Illinois at Urbana-Champaign)
Authors:
Katelyn Dahlke
(University of Illinois at Urbana-Champaign)
Charles E. Sing
(University of Illinois at Urbana-Champaign)
We use coarse-grained simulation of NAPs and DNA that allow us to achieve the time and length scales where DNA supercoiling occurs. Supercoils are twist-induced structures that are the result of relaxing highly-twisted DNA by inducing higher degrees of bending and writhe. This model can capture experimentally observed supercoiling behavior, and also shows that NAPs that locally bend DNA enhance DNA supercoiling. We are able to show that NAPs tend to localize along the contour of the supercoil, and this binding preference is capable of stabilizing supercoils that form within the nucleoid. By tracking different energies within the system, such as the energy due to bending, extension, or excluded volume, we gain insights into what is driving this protein-mediated supercoiling.
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700