Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session H63: Physics of Microbiomes and Microbial Communities II
2:30 PM–5:30 PM,
Tuesday, March 5, 2019
BCEC Room: 259A
Sponsoring Unit: DBIO
Chair: Raghuveer Parthasarathy, University of Oregon
Abstract: H63.00004 : Community coexistence and stability: insights from a mediator-explicit model of microbial interactions*
3:30 PM–3:42 PM
We formulate and experimentally constrain a model that explicitly incorporates chemical compounds (e.g. metabolites or waste-products) that can mediate microbial interactions. In a continuous-growth setting where resources are supplied (similar to a bioreactor or gut microbiota), our model highlights facilitation and self-restraint as interactions that contribute to coexistence. We show that when interactions are strong, coexistence and stability are determined primarily by the topology of facilitation and inhibition influences and not the strengths of influences. Importantly, we show that consumption of chemical mediators moderates interaction strengths and promotes coexistence. Our results offer insights into how to build or restructure microbial communities of interest.
*This work is supported by an Award for Excellence in Biomedical Research from the Smith Family Foundation.
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