Bulletin of the American Physical Society
APS March Meeting 2018
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session X49: Evolutionary Dynamics of Genomes II
8:00 AM–10:12 AM,
Friday, March 9, 2018
LACC Room: 511A
Sponsoring Units: DBIO GSNP
Chair: Benjamin Greenbaum, Mount Sinai Sch of Med
Abstract: X49.00008 : Synergistic Interactions between Host Immunity, Phage and Commensal Bacteria in Controlling Bacterial Pathogens*
9:48 AM–10:00 AM
(School of Biological Sciences and School of Physics, Georgia Inst of Tech)
The host immune system is a critical driver of within-host dynamics of pathogens. However, there is limited understanding of the tripartite interactions between host immunity, pathogenic bacteria and antimicrobials. Combining nonlinear dynamic models and animal experiments, we have recently shown how host immunity can clear an acute respiratory infection in synergy with phage (viruses that exclusively infect bacteria) [1, 2]. As a consequence of this synergy, phage and host immunity can eliminate multidrug-resistant bacterial pathogens, even when neither phage nor the immune response can do so alone. Here, we extend our theoretical framework to include potential synergies between host immunity and commensal or probiotic bacteria. By incorporating competition between commensal and pathogenic bacteria, our results suggest that host immunity can act synergistically with commensals to eliminate bacterial pathogens by tipping the balance between beneficial and pathogenic bacterial populations. We will discuss the implications of our results for phage and probiotic therapies.
 D. R. Roach and C. Y. Leung et al., Cell Host Microbe 22, 38 (2017).
 C. Y Leung and J. S. Weitz, J. Theor. Biol. 429, 241 (2017).
*This work is supported by Army Research Office grant W911NF-14-1-0402.
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700