Bulletin of the American Physical Society
APS March Meeting 2018
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session S49: Evolutionary Dynamics of Genomes I
11:15 AM–2:27 PM,
Thursday, March 8, 2018
LACC Room: 511A
Sponsoring Units: DBIO GSNP
Chair: Edo Kussell, New York University
Abstract: S49.00001 : Exploratory adaptation in gene regulatory networks
11:15 AM–11:51 AM
I will review experimental evidence for exploratory behavior in gene regulation, that stabilizes adaptive phenotypes in single cells with high probability and relatively short timescales. I will then present a model of gene regulatory networks which demonstrates the capacity for such adaptation. The model addresses the problem of convergence of exploration in high-dimensional spaces. It shows that such convergence is non-universal and depends on network properties: it requires outgoing network hubs and is enhanced by their auto-regulation. The ability of these empirically validated features of gene regulatory networks to support exploratory adaptation without fine-tuning, makes it a biologically plausible mechanism for primitive cellular learning.
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