Bulletin of the American Physical Society
APS March Meeting 2018
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session R58: Controlling Space and Time in Biology: From Gene Regulation in a Single Cell to Pattern Formation in Cell Populations and Development
8:00 AM–11:00 AM,
Thursday, March 8, 2018
LACC Room: Petree Hall C
Sponsoring Unit: DBIO
Chair: Yuhai Tu, IBM T J Watson Research Center
Abstract: R58.00003 : Adapt to oscillate: a nonequilibrium thermodynamic view of dynamic quorum sensing*
9:12 AM–9:48 AM
(Complex Systems Division, Beijing Computational Science Research Center)
(Department of Physics, Hong Kong Baptist Univ)
Cell-density-dependent rhythmic behavior, or dynamic quorum sensing, has been suggested to coordinate population level activities such as cell migration and embryonic development. Quantitative description of the oscillatory phenomenon is hitherto hampered by incomplete knowledge of the underlying intracellular processes, especially when isolated cells appear to be quiescent. Here we present a nonequilibrium thermodynamic scenario where adaptive sensing drives the oscillation of a dissipative signaling field through stimulated energy release. We prove, on general grounds, that adaptation implies phase reversal of the linear response function in a certain frequency domain, in violation of the fluctuation-dissipation theorem (FDT) under restricted coupling between a cell and the signal. Consequently, at sufficiently strong coupling, an oscillating signal in a suitable frequency range becomes self-sustained due to the energy outflow from adaptive cells. We find this overarching principle to be at work in several natural and synthetic oscillatory systems, and it may help to guide the design of further experiments on glycolytic oscillation in yeast suspensions.
 Shou-Wen Wang and Lei-Han Tang, arXiv:1611.04089.
 Shou-Wen Wang and Lei-Han Tang, submitted.
*Work supported in part by the RGC of the HKSAR under 12301514, and by the NSFC under grants U1430237 and 11635002.
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