Bulletin of the American Physical Society
APS March Meeting 2018
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session K59: Designing Biomacromolecules for Materials Assembly
8:00 AM–11:00 AM,
Wednesday, March 7, 2018
LACC Room: Petree Hall D
Sponsoring Units: DPOLY DBIO
Chair: Darrin Pochan, Univ of Delaware
Abstract: K59.00004 : Materials Science & Nanotechnology with Protein Nanofibrils
9:48 AM–10:24 AM
(ETH - Zurich)
(ETH - Zurich)
Protein fibrils are protein aggregates, which can be generated from food-grade proteins by unfolding and hydrolysis. The resulting protein fibrils can be used in a broad context of applications. At length scales above the well-established atomistic fingerprint of amyloid fibrils, these colloidal aggregates exhibit mesoscopic properties comparable to those of natural polyelectrolytes, yet with persistence lengths several orders of magnitude beyond the Debye length. This intrinsic rigidity, together with their chiral, polar and charged nature, provides these systems with some unique physical behavior. In this talk I will discuss our current understanding on the mesoscopic properties of amyloid fibrils at the single molecule level, the implication of their semiflexible nature on their liquid crystalline properties, and I will illustrate how this information prove useful in understanding their collective behavior in bulk and when adsorbed at liquid interfaces. By the careful exploitation of the physical properties of amyloid fibrils, the design of advanced materials with unprecedented physical properties become possible, and I will give a few examples on how these systems can ideally suit the design of biosensors, biomaterials, cellular scaffolds, catalytic and water purification membranes and even shuttles for in-vivo bioavailable nanostructured iron, with a real-cost-effective return, making them promising candidates for building blocks in advanced materials and state of the art nanotechnologies.
1) S Bolisetty & R Mezzenga, Amyloid–carbon hybrid membranes for universal water purification. Nature Nanotechnology, 11, 365 , 2016.
2) Y Shen et al. Amyloid fibril systems reduce, stabilize and deliver bioavailable nanosized iron. Nature Nanotechnology, 12, 642 , 2017.
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