Bulletin of the American Physical Society
APS March Meeting 2018
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session K49: Physics of Genome Organization: From DNA to Chromatin I
8:00 AM–10:48 AM,
Wednesday, March 7, 2018
LACC Room: 511A
Sponsoring Units: DBIO DPOLY GSNP
Chair: Ralf Bundschuh, Ohio State University
Abstract: K49.00005 : Properties of Gene Expression and Chromatin Structure with Mechanically Regulated Transcription
9:12 AM–9:24 AM
The mechanical properties of transcription have emerged as central elements in our understanding of gene expression. Recent work has been done introducing a simple description of the basic physical elements of transcription where RNA elongation, RNA polymerase (RNAP) rotation and DNA super-coiling are coupled. Here we generalize this framework to accommodate the behavior of many RNAPs operating on multiple genes on a shared piece of DNA. The resulting framework is combined with well-established stochastic processes of transcription resulting in a model which characterizes the impact of the mechanical properties of transcription on gene expression and DNA structure. Transcriptional bursting readily emerges as a common phenomenon with origins in the geometric nature of the genetic system and results in the bounding of gene expression statistics. Properties of a multiple gene system are examined with special attention paid to the role that genome composition (gene orientation, size, and intergenic distance) plays in the ability of genes to transcribe. The role of transcription in shaping DNA structure is examined and the possibility of transcription driven domain formation is discussed.
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