Bulletin of the American Physical Society
APS March Meeting 2018
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session B47: Physics of Multicellular Information Processing
11:15 AM–2:15 PM,
Monday, March 5, 2018
LACC Room: 507
Sponsoring Unit: DBIO
Chair: Bo Sun, Oregon State Univ
Abstract: B47.00011 : On public and private aspects of the adaptive immune system as revealed by statistical inference
2:03 PM–2:15 PM
We have learned how to infer probabilistic models that capture the statistics of the T cell ensemble carried by individuals. A key feature of these models is that individual immune cells are produced with different likelihoods, with the distribution of generation probabilities spanning many decades. The statistical power of our models enables us to compare samples from different individuals or compartments. We use the models to predict how many receptors (both in number and in specific receptor sequences) will be shared between any number of individuals, simply as a result of the biased generation statistics. We show results for mice and men and draw conclusions about the predictability of a stochastic immune system.
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700