Bulletin of the American Physical Society
APS March Meeting 2018
Volume 63, Number 1
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session A49: Biomaterials 1: Structure, Function, Design
8:00 AM–10:48 AM,
Monday, March 5, 2018
LACC
Room: 511A
Sponsoring
Units:
DBIO DCP
Chair: Pupa Gilbert, Univ of Wisconsin, Madison
Abstract ID: BAPS.2018.MAR.A49.6
Abstract: A49.00006 : Targeting the Mechanical Properties of Biofilms for New Approaches to Treating Infections*
9:24 AM–9:36 AM
Presenter:
Kristin Kovach
(Physics, Univ of Texas, Austin)
Authors:
Kristin Kovach
(Physics, Univ of Texas, Austin)
Megan Davis-Fields
(Microbiology, Univ of Texas, Austin)
Layla Bakhtiari
(Physics, Univ of Texas, Austin)
Vernita Gordon
(Physics, Univ of Texas, Austin)
We use bulk rheology and atomic force microscopy to characterize the mechanical impact of different matrix polymers produced by the human pathogen Pseudomonas aeruginosa. We find that these biofilms create their strongest matrices by producing polymers of long chains with high ductility in combination with polymers that form stiff cross-linked networks. By targeting these ductile chains or the link-points of these networks, we can subsequently target the individual mechanics of the bacterial biofilm. Building on this, we intend to determine how attacking specific mechanical properties of biofilms can make biofilms more vulnerable to clearance by the immune system.
*NSF GRFP
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.MAR.A49.6
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