Bulletin of the American Physical Society
APS March Meeting 2017
Volume 62, Number 4
Monday–Friday, March 13–17, 2017; New Orleans, Louisiana
Session X21: Physics of Proteins: Novel Methods Revealing New InsightsInvited
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Sponsoring Units: DPOLY DBIO Chair: Dongping Zhong, Ohio State University Room: 281-282 |
Friday, March 17, 2017 8:00AM - 8:36AM |
X21.00001: Optical multiple-dimension spectroscopy of photosynthetic systems Invited Speaker: Greg Engel |
Friday, March 17, 2017 8:36AM - 9:12AM |
X21.00002: New strategy for protein interactions and application to structure-based drug design Invited Speaker: Xiaoqin Zou One of the greatest challenges in computational biophysics is to predict interactions between biological molecules, which play critical roles in biological processes and rational design of therapeutic drugs. Biomolecular interactions involve delicate interplay between multiple interactions, including electrostatic interactions, van der Waals interactions, solvent effect, and conformational entropic effect. Accurate determination of these complex and subtle interactions is challenging. Moreover, a biological molecule such as a protein usually consists of thousands of atoms, and thus occupies a huge conformational space. The large degrees of freedom pose further challenges for accurate prediction of biomolecular interactions. Here, I will present our development of physics-based theory and computational modeling on protein interactions with other molecules. The major strategy is to extract microscopic energetics from the information embedded in the experimentally-determined structures of protein complexes. I will also present applications of the methods to structure-based therapeutic design. [Preview Abstract] |
Friday, March 17, 2017 9:12AM - 9:48AM |
X21.00003: Cryo-EM visualization of the protein machine that replicates the chromosome Invited Speaker: Huilin Li Structural knowledge is key to understanding biological functions. Cryo-EM is a physical method that uses transmission electron microscopy to visualize biological molecules that are frozen in vitreous ice. Due to recent advances in direct electron detector and image processing algorithm, cryo-EM has become a high-resolution technique. Cryo-EM field is undergoing a rapid expansion and vast majority research institutions and research universities around the world are setting up cryo-EM research. Indeed, the method is revolutionizing structural and molecular biology. We have been using cryo-EM to study the structure and mechanism of eukaryotic chromosome replication. Despite an abundance of cartoon drawings found in review articles and biology textbooks, the structure of the eukaryotic helicase that unwinds the double stranded DNA has been unknown. It has also been unknown how the helicase works with DNA polymerases to accomplish the feat of duplicating the genome. In my presentation, I will show how we have used cryo-EM to derive at structures of the eukaryotic chromosome replication machinery and describe mechanistic insights we have gleaned from the structures. [Preview Abstract] |
Friday, March 17, 2017 9:48AM - 10:24AM |
X21.00004: Single Molecule Enzymology via Nanoelectronic Circuits Invited Speaker: Philip Collins Traditional single-molecule techniques rely on fluorescence or force transduction to monitor conformational changes and biochemical activity. Recent demonstrations of single-molecule monitoring with electronic transistors are poised to add to the single-molecule research toolkit. The transistor-based technique is sensitive to the motion of single charged side chain residues and can transduce those motions with microsecond resolution, opening the doors to single-molecule enzymology with unprecedented resolution. Furthermore, the solid-state platform provides opportunities for parallelization in arrays and long-duration monitoring of one molecule's activity or processivity, all without the limitations caused by photo-oxidation or mutagenic fluorophore incorporation. This presentation will review some of these advantages and their particular application to DNA polymerase I processing single-stranded DNA templates. [Preview Abstract] |
Friday, March 17, 2017 10:24AM - 11:00AM |
X21.00005: From channel rhodopsins to optogenetics Invited Speaker: Peter Hegemann |
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