Bulletin of the American Physical Society
APS March Meeting 2014
Volume 59, Number 1
Monday–Friday, March 3–7, 2014; Denver, Colorado
Session Q40: Invited Session: Cell Motility in Three-Dimensions
2:30 PM–5:30 PM,
Wednesday, March 5, 2014
Room: Mile High Ballroom 2B-3B
Sponsoring Units: DBIO DFD
Chair: Moumita Das, Rochester Institute of Technology
Abstract ID: BAPS.2014.MAR.Q40.5
Abstract: Q40.00005 : Tumor cell migration is a superstatistical process*
4:54 PM–5:30 PM
Preview Abstract Abstract
(Department of Physics, University of Erlangen-Nuremberg)
Over short time scales, cell migration can be well described as a homogeneous correlated random walk with a fixed average step length and a certain degree of directional persistence. On time scales of up to 24 h, however, the migration process is highly inhomogeneous. Superstatistical fluctuations of step length and directional persistence lead to ``anomalous'' features, such as an exponential step width distribution (SWD) and a superdiffusive mean squared displacement (MSD). These features are quantitatively reproduced by a correlated random walk with temporally varying persistence. By comparing cell migration on planar substrates and in a 3D collagen matrix, we demonstrate that the globally averaged MSD and SWD are not sensitive to the microscopic migration mechanism of the cells and can therefore yield identical results in these different environments. By contrast, the temporal fluctuations of step length and directional persistence, and their mutual correlations, provide a characteristic fingerprint of the migration process in different environments.
*In collaboration with Julian Steinwachs and Claus Metzner, Department of Physics, University of Erlangen-Nuremberg.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2014.MAR.Q40.5
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700