Bulletin of the American Physical Society
APS March Meeting 2013
Volume 58, Number 1
Monday–Friday, March 18–22, 2013; Baltimore, Maryland
Session F45: Focus Session: Physics of Proteins I
8:00 AM–11:00 AM,
Tuesday, March 19, 2013
Hilton Baltimore Room: Holiday Ballroom 4
Sponsoring Units: DBIO DPOLY
Chair: Aihua Xie, Oklahoma State
Abstract ID: BAPS.2013.MAR.F45.10
Abstract: F45.00010 : Intermediate Resolution Models and Protein Folding and Allostery*
10:12 AM–10:24 AM
Preview Abstract Abstract
(Iowa State University)
(Iowa State University and Ames Lab)
Intermediate Resolution Models (IRM)s model proteins with nearly all atom precision but consider solvent implicitly, and treat electrostatics as short-range interactions. In this talk, we describe a new IRM. We discuss its differences from other existing IRMs and test it again a set of 13 proteins. The model successfully folds 12 of them into its native state, starting from a random configuration. The stability of the native state versus other states with different topologies (arrangement of the secondary structure) is also discussed. Implications for general protein motion are also presented.
*This work is supported by NSF, through grant DMR-0748475.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2013.MAR.F45.10
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