Bulletin of the American Physical Society
APS March Meeting 2013
Volume 58, Number 1
Monday–Friday, March 18–22, 2013; Baltimore, Maryland
Session A47: Invited Session: Excitable Dynamics in Biological Systems |
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Sponsoring Units: DBIO Chair: Pankaj Mehta, Boston University Room: Hilton Baltimore Holiday Ballroom 6 |
Monday, March 18, 2013 8:00AM - 8:36AM |
A47.00001: Cell signaling at the single-cell level Invited Speaker: Michael Elowitz |
Monday, March 18, 2013 8:36AM - 9:12AM |
A47.00002: Excitability in Dictyostelium development Invited Speaker: David Schwab Discovering how populations of cells reliably develop into complex multi-cellular structures is a key challenge in modern developmental biology. This requires an understanding of how networks at the single-cell level, when combined with intercellular signaling and environmental cues, give rise to the collective behaviors observed in cellular populations. I will present work in collaboration with the Gregor lab, showing that the signal-relay response of starved cells of the amoebae Dictyostelium discoideum can be well modeled as an excitable system. This is in contrast to existing models of the network that postulate a feed-forward cascade. I then extend the signal-relay model to describe how spatial gradient sensing may be achieved via excitability. One potential advantage of relying on feedback for gradient sensing is in preventing ``cheaters'' that do not produce signals from taking over the population. I then combine these models of single-cell signaling and chemotaxis to perform large-scale agent-based simulations of aggregating populations. This allows direct study of how variations in single-cell dynamics modify population behavior. In order to further test this model, I use the results of a screen for mutant cell lines that exhibit altered collective patterns. Finally, I use an existing FRET movie database of starved cell populations at varying cell densities and dilution rates to study heterogeneity in repeated spatio-temporal activity patterns. [Preview Abstract] |
Monday, March 18, 2013 9:12AM - 9:48AM |
A47.00003: Excitability in neural coding Invited Speaker: Adrienne Fairhall |
Monday, March 18, 2013 9:48AM - 10:24AM |
A47.00004: Action Potential Initiation in the Hodgkin-Huxley Model Invited Speaker: Michael Brenner |
Monday, March 18, 2013 10:24AM - 11:00AM |
A47.00005: Cell motility: Combining experiments with modeling Invited Speaker: Wouter-Jan Rappel Cell migration and motility is a pervasive process in many biology systems. It involves intra-cellular signal transduction pathways that eventually lead to membrane extension and contraction. Here we describe our efforts to combine quantitative experiments with theoretical and computational modeling to gain fundamental insights into eukaryotic cell motion. In particular, we will focus on the amoeboid motion of Dictyostelium discoideum cells. [Preview Abstract] |
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