Bulletin of the American Physical Society
APS March Meeting 2013
Volume 58, Number 1
Monday–Friday, March 18–22, 2013; Baltimore, Maryland
Session A45: Focus Session: Structure and Dynamics of Biomembranes I
8:00 AM–10:48 AM,
Monday, March 18, 2013
Hilton Baltimore Room: Holiday Ballroom 4
Sponsoring Units: DBIO DPOLY
Chair: Fredrick Heberle, Oak Ridge National Laboratory
Abstract ID: BAPS.2013.MAR.A45.1
Abstract: A45.00001 : Molecular simulation studies of edges in bilayers and bicelles*
8:00 AM–8:36 AM
Preview Abstract Abstract
(Emory University, Department of Chemistry)
The instability of the free edge of a lipid bilayer can be quantified by a line tension, or excess free energy per unit length of the edge. Atomistic simulations of bilayer ribbons composed of a series of lipids with varying tail lengths and degrees of saturation have been performed to determine line tensions, with the goal of relating edge stability to structural and elastic properties of the bilayer. Line tensions are relevant to the mechanical stability of bilayer membranes, and can be reduced or eliminated by the inclusion of edge-stabilizing molecules (edge-actants) to the bilayer system. Mixtures of long- and short-tailed phospholipids are known to form aggregates known as ``bicelles'' that contain bilayers with stable edges. Simulations of ``bicelle'' mixtures using coarse-grained and atomistic lipid models have been performed to study the partitioning of short-tailed lipids towards the edge and the flexibility of the stabilized edge. Input from these simulations has been used in the development of simple thermodynamic models to rationalize some aspects of bicelle aggregate morphology.
*This work was supported by NSF grant CHE-0911285.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2013.MAR.A45.1
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