Bulletin of the American Physical Society
APS March Meeting 2012
Volume 57, Number 1
Monday–Friday, February 27–March 2 2012; Boston, Massachusetts
Session W42: Focus Session: The Physics of Genome Folding I: Fractal Globules and Condensed Polymer States
11:15 AM–2:15 PM,
Thursday, March 1, 2012
Sponsoring Units: DBIO DPOLY
Chair: Erez Lieberman Aiden, Harvard Society of Fellows
Abstract ID: BAPS.2012.MAR.W42.1
Abstract: W42.00001 : How the genome folds*
11:15 AM–11:51 AM
Preview Abstract Abstract
Erez Lieberman Aiden
(Harvard Society of Fellows)
I describe Hi-C, a novel technology for probing the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. Working with collaborators at the Broad Institute and UMass Medical School, we used Hi-C to construct spatial proximity maps of the human genome at a resolution of 1Mb. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and closed chromatin to form two genome-wide compartments. At the megabase scale, the chromatin conformation is consistent with a fractal globule, a knot-free conformation that enables maximally dense packing while preserving the ability to easily fold and unfold any genomic locus. The fractal globule is distinct from the more commonly used globular equilibrium model. Our results demonstrate the power of Hi-C to map the dynamic conformations of whole genomes.
*E.L.A. is supported by NIH Grants 1P50HG006193-01 (Center for Cell Circuits) and 1DP2OD008540-01 (NIH New Innovator Award).
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2012.MAR.W42.1
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700