Session W50: Focus Session: Micro and Nano Fluidics I: Devices and Applications

11:15 AM–2:15 PM, Thursday, March 1, 2012
Room: 162B

Sponsoring Units: DPOLY DFD
Chair: Dongshin Kim, Brandeis University

Abstract ID: BAPS.2012.MAR.W50.9

Abstract: W50.00009 : Creating 3D chemical gradients with self-folding microfluidic networks

1:15 PM–1:27 PM

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  Mustapha Jamal
    (Chemical and Biomolecular Engineering, Johns Hopkins University)

  Yevgeniy Kalinin
    (Chemical and Biomolecular Engineering, Johns Hopkins University)

  Aasiyeh Zarafshar
    (Chemical and Biomolecular Engineering, Johns Hopkins University)

  David Gracias
    (Chemical and Biomolecular Engineering, Johns Hopkins University)

We describe the reversible self-folding of polymeric films into intricate three-dimensional (3D) microfluidic networks and investigate their utility as bio-inspired synthetic vasculature for in vitro tissue culture models. Our fabrication methodology relies on patterning of channels inside the films at the planar microfabrication stage followed by programmable self-folding of the two-dimensional patterned structures. Here self-folding action is enabled by stress gradients which develop in the films due to differential ultraviolet cross-linking and subsequent solvent conditioning. We achieved wafer-scale assembly of micropatterned geometries including helices, polyhedra and corrugated sheets. To demonstrate utility of such self-folded microfluidic devices we present localized chemical delivery of biochemicals in 3D to discrete regions of cells cultured on the curved self-assembled surfaces and in a thick, surrounding hydrogel. We believe that the devices can be used to mimic such natural self-assembled systems as leaves and tissues. Reference: M. Jamal et al., Nature Communications (2011; in press).

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