Session B41: Lipid Bilayers and Biological Membranes

11:15 AM–2:15 PM, Monday, February 27, 2012
Room: 156B

Sponsoring Unit: DBIO
Chair: Jianjun Pan, Oak Ridge National Laboratory

Abstract ID: BAPS.2012.MAR.B41.9

Abstract: B41.00009 : Modeling curvature-dependent subcellular localization of a small sporulation protein in Bacillus subtilis

12:51 PM–1:03 PM

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  Vaibhav Wasnik
    (Department of Physics, Clark University)

  Ned Wingreen
    (Princeton University)

  Ranjan Mukhopadhyay
    (Department of Physics, Clark University)

Recent experiments suggest that in the bacterium, B. subtilis, the cue for the localization of small sporulation protein, SpoVM, that plays a central role in spore coat formation, is curvature of the bacterial plasma membrane. This curvature-dependent localization is puzzling given the orders of magnitude difference in lengthscale of an individual protein and radius of curvature of the membrane. Here we develop a minimal model to study the relationship between curvature-dependent membrane absorption of SpoVM and clustering of membrane-associated SpoVM and compare our results with experiments.

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