Bulletin of the American Physical Society
APS March Meeting 2011
Volume 56, Number 1
Monday–Friday, March 21–25, 2011; Dallas, Texas
Abstract: S1.00222 : A multiscale model for nanoparticle binding dynamics under shear flow
Author:
Nanomedicine poses a new frontier in medical technology with the
advantages
of targeted delivery and patient specific design. In applications of
nanoparticle targeted drug delivery, the delivery efficiency is
controlled
by the physical properties of the nanoparticle such as its size,
shape,
ligand density, as well as external environmental conditions such
as blood
flow rate, blood vessel diameter. Proper drug dosage choice
relies on
determination of the attachment and detachment rates of the
nanoparticles at
the active region and the understanding of the complex process of
targeted
drug delivery. A few particulate models have been proposed to
study the
adhesion probability of individual spherical or non-spherical
nanoparticles.
Meanwhile, continuum convection-diffusion-reaction models have
been widely
used to calculate the drug concentration, which usually assumes
specific
binding and de-binding constants. However, there has not been any
study that
links the particulate level nanoparticle size and shape
information to the
system level bounded particle concentration. A hybrid particle
binding
dynamics and continuum convection-diffusion-reaction model is
presented to
study the effect of shear flow rate and particle size on binding
efficiency.
The simulated concentration of bounded nanoparticles agrees well
with
experimental results in flow chamber studies.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.S1.222
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