Bulletin of the American Physical Society
APS March Meeting 2011
Volume 56, Number 1
Monday–Friday, March 21–25, 2011; Dallas, Texas
Abstract: S1.00133 : Analysis of Striped Nanoparticle Complexation with Lipid Bilayers
Author:
A recent study has shown that a new class of synthetic
ligand-protected gold
nanoparticles is able to penetrate the cell membrane without
inducing
poration or endocytosis. Furthermore, these nanoparticles fuse
with pure
lipid bilayers while retaining high solubility in biological
conditions.
This complexation behavior is related to the morphology of the
ligand shell,
which is composed of alternating ribbon-like domains of linear
alkanes with
either hydrophobic or charged end-groups. Spontaneous
complexation is
surprising given the large free energy barrier for moving charges
through
the hydrophobic bilayer core. In this work, we provide a
thermodynamic
analysis of bilayer complexation supported by multiscale
simulations. We
show that the key to bilayer complexation is the rearrangement of
ligands by
bending to maximize hydrophobic matching and minimize charge
exposure. We
believe this result will improve our understanding of
transmembrane proteins
and enable the design of nanoparticles for drug delivery and
biosensing
applications.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.S1.133
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