APS March Meeting 2011
Volume 56, Number 1
Monday–Friday, March 21–25, 2011;
Dallas, Texas
Abstract: Q7.00004 : Towards a Quantitative Endogenous Network Theory of Cancer Genesis and Progression: beyond ``cancer as diseases of genome''
1:03 PM–1:39 PM
Preview Abstract
Author:
There has been a tremendous progress in cancer research. However,
it appears the current dominant cancer research framework of
regarding cancer as diseases of genome leads impasse. Naturally
questions have been asked that whether it is possible to develop
alternative frameworks such that they can connect both to
mutations and other genetic/genomic effects and to environmental
factors. Furthermore, such framework can be made quantitative and
with predictions experimentally testable. In this talk, I will
present a positive answer to this calling. I will explain on our
construction of endogenous network theory based on
molecular-cellular agencies as dynamical variable. Such cancer
theory explicitly demonstrates a profound connection to many
fundamental concepts in physics, as such stochastic
non-equilibrium processes, ``energy'' landscape, metastability,
etc. It suggests that neneath cancer's daunting complexity may
lie a simplicity that gives grounds for hope. The rationales
behind such theory, its predictions, and its initial experimental
verifications will be presented.
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References:\\[0pt]
[1] Cancer as Robust Intrinsic State of Endogenous
Molecular-Cellular Network Shaped by Evolution. P. Ao, D. Galas,
L. Hood, X.-M. Zhu, Medical Hypotheses \textbf{70} (2008) 678-684.
http://dx.doi.org/10.1016/j.mehy.2007.03.043\\[0pt]
[2] Towards Predictive Stochastic Dynamical Modeling of Cancer
Genesis and Progression. P. Ao, D. Galas, L. Hood, L.Yin,
X.M.Zhu. Interdiscip Sci Comput Life Sci (2010) 2: 140-144
DOI: 10.1007/s12539-010-0072-3\\[0pt]
[3] Orders of Magnitude Change in Phenotype Rate Caused by
Mutations. P. Ao, Cellular Oncology (2007) \textbf{29}: 67-69.
http://arxiv.org/PS\_cache/arxiv/pdf/0704/0704.0429v1.pdf
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.Q7.4