APS March Meeting 2011
Volume 56, Number 1
Monday–Friday, March 21–25, 2011;
Dallas, Texas
Abstract: P16.00007 : Geometrically Confined Spin Vortices: from Fundamental Physics to Biomedical Applications
9:12 AM–9:48 AM
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Author:
The magnetic ground state of magnetically soft thin film
ferromagnets in
confined geometries (on the micrometer scale) consists of a
curling spin
configuration, known as a magnetic vortex state. We have recently
demonstrated that the magnetic vortex microdisks can be
successfully used as
multifunctional magnetic carriers for biomedicine [1]. In
particular, we
will report on successful interfacing of ferromagnetic
nanomaterials with a
spin vortex ground state and biomaterials (antibody, whole cell).
Namely,
the gold-coated lithographically defined microdisks with an Fe-Ni
magnetic
core were biofunctionalized with anti-human-IL13a2R antibody for
specifically targeting human glioblastoma cells. When an alternating
magnetic field is applied the vortices shift, leading to the
microdisks
oscillation that causes a mechanical force to be transmitted to
the cell.
Cytotoxicity assays, along with optical and atomic force
microscopy studies,
show that the spin vortex-mediated stimulus creates two dramatic
effects:
(a) membrane disturbance and compromising, and (b) cellular signal
transduction and amplification, leading to robust DNA
fragmentation and,
finally, programmed cell death [2]. The experiments reveals that by
employing biofunctionalized magnetic vortex microdisks the
magnetic fields
of low frequency of ~a few tens of Hz ~and of small amplitude of
$<$ 100 Oe
applied during only 10 minutes was sufficient to achieve $\sim
$90{\%}
cancer cells destruction.
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[1] E. A. Rozhkova, et al., J. Appl. Phys. Vol. 105, (2009) 07B306.
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[2] D.-H. Kim, et al., Nature Materials, vol. 9, pp. 165 - 171
(2010).
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.P16.7