Session Y38: Focus Session: Non-Equilibrium Insights into Single Molecules and Cell Function II
8:00 AM–10:48 AM, Friday, March 25, 2011
Room: A130/131
Sponsoring Units:
DCP DBP
Chair: Aaron Dinner, University of Chicago
Abstract ID: BAPS.2011.MAR.Y38.4
Abstract: Y38.00004 : Non-equilibrium microrheology of living cells
9:48 AM–10:00 AM
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Abstract 
Authors:
Ming-Tzo Wei
(Bioengineering, Lehigh University, Bethlehem, PA, USA 18015)
H. Daniel Ou-Yang
(Physics and Bioengineering, Lehigh University, Bethlehem, PA, USA 18015)
Intracellular stresses generated by molecular motors can actively modify cytoskeletal network and change intracellular mechanical properties. We study the out-of-equilibrium microrheology in living cells using endogenous organelle particles as probes. This paper reports measurements of the intracellular mechanical properties using passive, particle-tracking and active, optical tweezers-based microrheology approaches. Using arguments based on the fluctuation-dissipation theorem, we compared the results from both approaches to distinguish thermal and non-thermal mechanical fluctuations in living cells.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.Y38.4