Session V43: Focus Session: Translocation Through Nanopores II
8:00 AM–11:00 AM, Thursday, March 24, 2011
Room: A306/307
Sponsoring Units:
DPOLY DBP
Chair: Johan Dubbeldam, Delft University of Technology, Netherlands
Abstract ID: BAPS.2011.MAR.V43.2
Abstract: V43.00002 : DNA translocation through a solid-state nanopore coated with a self-assembled monolayer
8:12 AM–8:24 AM
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Abstract 
Authors:
Binquan Luan
Gustavo Stolovitzky
Glenn Martyna
The translocation of DNA through a solid-state nanopore can be dramatically affected by surface properties of a pore, such as charge density, roughness and hydrophobicity, since the pore surface serves as a boundary for the hydrodynamic flow accompanying with DNA motion. Recent experiment demonstrated the coating of a self-assembled monolayer (SAM) on the surface of a nanopore, allowing an active control on the surface property. Using all-atom molecular dynamics simulation, we investigated the tribological effect on DNA translocation through a solid-state nanopore coated with a SAM. When DNA is confined to the center of a pore, i.e. no direct interaction between DNA and pore surface, charge density and roughness of a pore surface can affect electroosmotic and hydrodynamic flows inside a nanopore, respectively. When allowing direct interaction between DNA and a SAM, adhesive interaction via hydrogen bonds can substantially increase friction force on DNA during translocation but repulsive interaction permits a fast translocation of DNA. We found two types of motion of DNA, stick-slip and steady-sliding, that are qualitatively explained using a Langevin-like model.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.V43.2