Session J2: Force Probes of Materials' Structure and Function
11:15 AM–2:15 PM, Tuesday, March 22, 2011
Room: Ballroom A2
Sponsoring Unit:
DCMP
Chair: Chris Hammel, Ohio State University
Abstract ID: BAPS.2011.MAR.J2.2
Abstract: J2.00002 : Consistency and discrepancy between single molecule force spectroscopy experiments and theoretical models
11:51 AM–12:27 PM
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Abstract 
Author:
Robert Ros
(Department of Physics, Arizona State University, Tempe, AZ 85287-1504)
Single molecule force spectroscopy is a well-established tool to study molecular interactions in a wide range of binding affinities on the single-molecule level. Information about the strength of the molecular bond can be quantified in terms of the dissociation rate k$_{off}$, and the reaction length x$_{b}$ (i.e., the distance between potential minimum and maximum along the direction of pulling). The analysis and interpretation of the underlying force-distance curves is still challenging and various models describing the experimental data are under discussion. In this talk, I will present experimental data for a protein-RNA interaction related to posttranscriptional regulation on the single molecule level, and the interaction between DNA bases forming two or three hydrogen bonds. I will use these examples to discuss the advantages and limitations of this technique, and the consistency and discrepancy to theoretical models.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.J2.2