Bulletin of the American Physical Society
APS March Meeting 2010
Volume 55, Number 2
Monday–Friday, March 15–19, 2010; Portland, Oregon
Session D27: Self-organization in Biological Cells and Tissue I
2:30 PM–5:30 PM,
Monday, March 15, 2010
Sponsoring Unit: DBP
Chair: Shane Hutson, Vanderbilt University
Abstract ID: BAPS.2010.MAR.D27.7
Abstract: D27.00007 : Monodisperse domains by proteolytic control of the coarsening instability*
4:06 PM–4:18 PM
Preview Abstract Abstract
The coarsening instability typically prevents steady-statecluster-size distributions. We show that proteolysis, or degradation coupled to the cluster size, leads to a novel fixed-point cluster size. Stochastic evaporative and condensative fluxes determine the width of the size distribution. We investigate how the peak size and width depend on number, interactions, and proteolytic rate. This proteolytic size-control mechanism can lead to interesting self-organization phenomena in biology. In particular, we demonstrate how this model is consistent with the experimental phenomenology of pseudo-pilus length control in bacterial type 2 secretion systems.
*This work was supported financially by NSERC, CIHR and ACENET. J. Derr thanks Human Frontier Science Program for funding.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2010.MAR.D27.7
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