Bulletin of the American Physical Society
APS March Meeting 2010
Volume 55, Number 2
Monday–Friday, March 15–19, 2010; Portland, Oregon
Session D27: Self-organization in Biological Cells and Tissue I
2:30 PM–5:30 PM,
Monday, March 15, 2010
Sponsoring Unit: DBP
Chair: Shane Hutson, Vanderbilt University
Abstract ID: BAPS.2010.MAR.D27.3
Abstract: D27.00003 : Membrane-mediated interactions drive the condensation and coalescence of FtsZ rings*
2:54 PM–3:06 PM
Preview Abstract Abstract
The role of the coupling between the shape of membrane-bound filaments, and the membrane, is demonstrated for the dynamics of FtsZ rings on cylindrical membranes. Filaments with an arc-like spontaneous curvature, and a possible added active contractile force, are shown to spontaneously condense into tight rings, associated with a local inwards deformation of the membrane. The long-range membrane-mediated interactions are attractive at short ring-ring separations, inducing the further coarsening dynamics, whereby smaller rings merge to form larger and fewer rings, that deform the membrane more strongly. At the same time, these interactions induce a potential barrier that can suppress further ring coalescence at a separation of about $2\pi$ times the cylinder radius. These results of the model are in very good agreement with recent in-vitro experiments on the dynamics of FtsZ filaments in cylindrical liposomes. These results emphasize the important role of long-range membrane-mediated interactions in the organization of cytoskeletal elements at the membrane.
*N.S.G. thanks the Alvin and Gertrude Levine Career Development Chair, for their support. This research was supported by the BSF (grant No. 2006285).
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2010.MAR.D27.3
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