Bulletin of the American Physical Society
APS March Meeting 2010
Volume 55, Number 2
Monday–Friday, March 15–19, 2010; Portland, Oregon
Session C1: Poster Session I (2:00 pm - 5:00 pm)
Monday, March 15, 2010
Room: Exhibit CD
Abstract ID: BAPS.2010.MAR.C1.278
Abstract: C1.00278 : Limits of Gradient Sensing and Information Transmission in Eukaryotic Cells*
Preview Abstract Abstract
Eukaryotic cells are able to direct their movements by sensing chemical gradients. The accuracy of such chemotactic response relies on the ability of cells to infer gradients from a heterogenous distribution of ligand-bound receptors on the membrane. Here, we use two different approaches, the maximum likelihood estimate (MLE) method and the partition function calculation, to explore the physical limits of eukaryotic gradient sensing. We further characterize the chemotaxing cell as a Markovian information processing system, and analytically derive the upper bounds on the cell capacity of information transmission. Our results suggest that both external and internal fluctuations are important limiting factors to chemotactic efficiency.
*This work was supported by NSF-CTBP grant no. PHY-0822283.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2010.MAR.C1.278
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