Bulletin of the American Physical Society
APS March Meeting 2010
Volume 55, Number 2
Monday–Friday, March 15–19, 2010; Portland, Oregon
Session C1: Poster Session I (2:00 pm - 5:00 pm)
Monday, March 15, 2010
Room: Exhibit CD
Abstract ID: BAPS.2010.MAR.C1.269
Abstract: C1.00269 : A Mathematical Analysis of of Second Messenger Compartmentalization in Neurons*
Preview Abstract Abstract
Recent experiments in hippocampal neurons have demonstrated the existence of compartments with elevated levels of second messenger molecules. This compartmentalization is believed to be necessary to ensure signaling specificity. Here we use analytical and numerical techniques to investigate the diffusion of a second messenger in the soma and the dendrite of a neuron. We obtain analytical solutions for the diffusion field and examine the limit in which the width of the dendrite is much smaller than the radius of the soma. We find that both the degradation rate and the width of the dendrite play a critical role in determining the concentration within the two compartments.
*This work was supported by the Center for Theoretical Biological Physics (NSF PHY-0822283).
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2010.MAR.C1.269
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