Bulletin of the American Physical Society
2009 APS March Meeting
Volume 54, Number 1
Monday–Friday, March 16–20, 2009; Pittsburgh, Pennsylvania
Session V27: Focus Session: Emerging Scanning Probe Microscopy Methods for Biological Applications
8:00 AM–10:48 AM,
Thursday, March 19, 2009
Sponsoring Unit: GIMS
Chair: Igor Sokolov, Clarkson University, Sergei Kalinin, Oak Ridge National Laboratory
Abstract ID: BAPS.2009.MAR.V27.4
Abstract: V27.00004 : AFM method to detect differences in adhesion of silica bids to cancer and normal epithelial cells*
9:00 AM–9:12 AM
Preview Abstract Abstract
(University of Western Australia)
To date, the methods of detection of cancer cells have been mostly based on traditional techniques used in biology, such as visual identification of malignant changes, cell growth analysis, specific ligand-receptor labeling, or genetic tests. Despite being well developed, these methods are either insufficiently accurate or require a lengthy complicated analysis. A search for alternative methods for the detection of cancer cells may be a fruitful approach. Here we describe an AFM study that may result in a new method for detection of cancer cells in vitro. Here we use atomic force microscopy (AFM) to study adhesion of single silica beads to malignant and normal cells cultured from human cervix. We found that adhesion depends on the time of contact, and can be statistically different for malignant and normal cells. Using these data, one could develop an optical method of cancer detection based on adhesion of various silica beads.
*Partial support from Nano-Bio Laboratory (NABLAB), Clarkson University and NSF CCR-0304143 is acknowledged.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2009.MAR.V27.4
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