Bulletin of the American Physical Society
2007 APS March Meeting
Volume 52, Number 1
Monday–Friday, March 5–9, 2007; Denver, Colorado
Session X3: DNA Organization within Chromosomes |
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Sponsoring Units: DCMP Chair: Ralf Bundschuh, The Ohio State University Room: Colorado Convention Center Korbel 2A-3A |
Friday, March 9, 2007 8:00AM - 8:36AM |
X3.00001: Structure and Dynamics of the Kinetochore Invited Speaker: |
Friday, March 9, 2007 8:36AM - 9:12AM |
X3.00002: Structural Organization and Properties of DNA in the Cell Invited Speaker: The dynamical architecture of the cell nucleus can be regarded as one of the ``grand challenges'' of modern molecular and structural biophysics. The genomic DNA and the histone proteins compacting it into chromatin account for the major part of the contents of the nucleus. In my talk I will discuss the structural properties of the DNA from the 30nm fiber up the entire chromosome. For the 30nm range I present a model for the compactifiction and discuss the resulting phase diagram. I am going to reveal the fine-structure of the excluded-volume borderline. Furthermore, the effect of the Coulomb repulsion of the DNA linkers will be presented. Moving up further in the range (300-800nm), we will look at the entanglements of the polymer chain. On the level of the entire chromosome I will present a model for the chain that can successfully describe experimentally measured distance distributions on chromosome 1 in human cells using the notion of ``ridge'' regions (cluster of strongly expressed genes) and the ``antiridge'' regions. [Preview Abstract] |
Friday, March 9, 2007 9:12AM - 9:48AM |
X3.00003: Dynamics of Single Molecule DNA Invited Speaker: |
Friday, March 9, 2007 9:48AM - 10:24AM |
X3.00004: The Torsonal Rigidity of Single Chromatin Fibers Invited Speaker: |
Friday, March 9, 2007 10:24AM - 11:00AM |
X3.00005: Dynamics of Nucleosome Arrays Invited Speaker: DNA sites wrapped into chromatin are sterically occluded from proteins that must bind for processes such as RNA transcription and DNA repair. However, the role of chromatin compaction in biological function is poorly understood. To understand the biological functions of chromatin compaction, we constructed nucleosome arrays that are built with a tandem repeat of high affinity nucleosome positioning sequences, which contain probes for DNA accessibility and chromatin structure. I will describe our results that use restriction enzyme digestion and fluorescence resonance energy transfer to determine the probability for DNA site exposure within compacted nucleosome arrays and the time scale for changes in chromatin compaction. I will then discuss how these results help explain how proteins gain access to DNA sites buried within chromatin. [Preview Abstract] |
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