Bulletin of the American Physical Society
2007 APS March Meeting
Volume 52, Number 1
Monday–Friday, March 5–9, 2007; Denver, Colorado
Session X2: Understanding DNA and RNA machines |
Hide Abstracts |
Sponsoring Units: DBP Chair: Meredith Betterton, University of Colorado Room: Colorado Convention Center Four Seasons 4 |
Friday, March 9, 2007 8:00AM - 8:36AM |
X2.00001: Invited Speaker: |
Friday, March 9, 2007 8:36AM - 9:12AM |
X2.00002: Invited Speaker: |
Friday, March 9, 2007 9:12AM - 9:48AM |
X2.00003: Hexameric DNA-based motor proteins Invited Speaker: Hexameric, ring-shaped motor proteins play important roles in a wide variety of cellular processes. They typically encircle a nucleic acid or protein substrate in order to perform a mechanical activity. Motivated by a desired to understand the advantages and peculiarities of this strikingly symmetric design, we have performed single-molecule measurements of several different DNA-based hexameric motors. I will discuss how, for the bacterial protein FtsK, the hexameric structure causes an anomalous coupling between rotation and linear motion. I will also present recent results in which we exploit the ability of certain hexameric helicases to encircle either single or double-stranded DNA in order to probe their activity in several different ways. Where relevant, I will introduce the novel magnetic-tweezer based measurement techniques we have devised for these experiments. [Preview Abstract] |
Friday, March 9, 2007 9:48AM - 10:24AM |
X2.00004: Stretching, Twisting, and Unzipping DNA Invited Speaker: DNA mechanics governs many essential cellular processes. During DNA replication, repair, recombination, and transcription, often a DNA double helix is unwound, its two strands are separated to expose the base sequence, and compensatory supercoils are generated in the remaining DNA. Our lab develops new single molecule optical trapping techniques to probe the mechanics of DNA as it is stretched, twisted, and unzipped. These approaches reveal interesting physical properties as well as permit direct investigation of the mechanisms of enzymes involved in these processes. I will discuss our recent work in these directions. [Preview Abstract] |
Friday, March 9, 2007 10:24AM - 11:00AM |
X2.00005: Invited Speaker: |
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700