Session B5: Adaptation in Biological Systems
11:15 AM–1:39 PM, Monday, March 5, 2007
Colorado Convention Center Room: Korbel 1A-1B
Sponsoring Unit:
DBP
Chair: Ned Wingreen, Princeton University
Abstract ID: BAPS.2007.MAR.B5.1
Abstract: B5.00001 : Precise Adaptation in Bacterial Chemotaxis through ``Assistance Neighborhoods''
11:15 AM–11:51 AM
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Author:
Robert Endres
(Princeton University)
The chemotaxis network in {\it Escherichia coli} is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals over a broad range of ambient concentrations. Key to this sensitivity is an adaptation system that relies on methylation and demethylation (or deamidation) of specific modification sites of the chemoreceptors by the enzymes CheR and CheB, respectively. It was recently discovered that these enzymes can access five to seven receptors when tethered to a particular receptor. We show that these ``assistance neighborhoods'' (ANs) are necessary for precise and robust adaptation in a model for signaling by clusters of chemoreceptors: (1) ANs suppress fluctuations of the receptor methylation level; (2) ANs lead to robustness with respect to biochemical parameters. We predict two limits of precise adaptation at large attractant concentrations: either receptors reach full methylation and turn off, or receptors become saturated and cease to respond to attractant but retain their adapted activity.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.MAR.B5.1