Bulletin of the American Physical Society
2006 APS March Meeting
Monday–Friday, March 13–17, 2006; Baltimore, MD
Session D9: Methods in Nanobiotechnology |
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Sponsoring Units: DBP Chair: Ido Braslavsky, Ohio University Room: Baltimore Convention Center 301 |
Monday, March 13, 2006 2:30PM - 3:06PM |
D9.00001: Nanomechanical Devices for Single Molecule Biophysics Invited Speaker: |
Monday, March 13, 2006 3:06PM - 3:42PM |
D9.00002: Single Molecule Dynamics of Polymers Confined in Nanochannels Invited Speaker: I will review our work on the conformational dynamics of polymers, in particular genomic length DNA molecules, in nanochannels whose diameter is less than the persistence length of the polymer. I will discuss how these dynamics give some insight into how nanochannels can be used for the next generation of single molecule mapping/sequencing techniques. [Preview Abstract] |
Monday, March 13, 2006 3:42PM - 4:18PM |
D9.00003: Surface-Mounted Artificial Dipolar Molecular Rotors Invited Speaker: We describe the synthesis, surface mounting, characterization, and operation of artificial molecular rotors of 1 - 3 nm size, attached to surfaces through one post (azimuthal rotors, axle normal to surface) or two posts (altitudinal rotors, axle parallel to surface). Rotor response to driving fields (electric and mechanical) has been simulated by molecular dynamics. [Preview Abstract] |
Monday, March 13, 2006 4:18PM - 4:54PM |
D9.00004: Mapping Protein Transport in Living Cells with Quantum Dots and Spatio-Temporal Image Correlation Spectroscopy Invited Speaker: We will present recent advances in image correlation methods and recent use of this technique in combination with luminescent quantum dots for measurements of protein transport in living cells. The talk will focus on the development of image correlation spectroscopy (ICS) as an imaging extension of fluorescence correlation spectroscopy (FCS). The ICS technique is ideally suited to measure transport and clustering of fluorescently tagged proteins in cellular membranes where transport is slow and static proteins abound. The image correlation methods are based on the measurement of fluorescence intensity fluctuations as a function of space and time collected as image time series using a laser scanning microscope (either confocal or two-photon). Spatial and temporal variants of the basic ICS method will be introduced and the power of these approaches to measure both aggregation and transport of cell surface proteins will be demonstrated. The use of luminescent quantum dots as labels for image correlation studies will be discussed including the effects of quantum dot blinking on the fluctuation based image correlation measurements. We will discuss appropriate models and image correlation analysis approaches for dealing with the quantum dot blinking including a new reciprocal space image correlation technique. Finally we will present experimental results from image correlation experiments using quantum dots for mapping protein transport fluid flows in living migrating cells. [Preview Abstract] |
Monday, March 13, 2006 4:54PM - 5:30PM |
D9.00005: STM Manipulation of Nanoscale Biomolecules Invited Speaker: The fascinating advances in single molecule manipulations with the scanning-tunneling-microscope (STM)-tip allow scientists to fabricate artificial atomic scale structures, to study local quantum phenomena or to investigate and control properties of molecules at an atomic limit. The STM manipulation is facilitated by a precise control of tip-molecule interactions, or tunneling electrons, or the electric field between the tip and sample. By combining STM manipulation with imaging and tunneling spectroscopy, powerful experimental schemes can be developed, which opens novel routes to investigate or induce molecular conformation changes with atomic level control. In this talk, various cutting-edge STM manipulation techniques relevant to the biological systems will be introduced and our recent results on manipulation of nanoscale biological molecules including chlorophyll-a, $\beta $-carotene and amyloid $\beta $/A4 precursor protein on a Au(111) substrate will be presented. [Preview Abstract] |
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