Session G26: Focus Session: Trapping of Nanoscale Biological Objects

8:00 AM–11:00 AM, Tuesday, March 14, 2006
Baltimore Convention Center Room: 323

Sponsoring Unit: DBP
Chair: W. E. Moerner, Stanford University

Abstract ID: BAPS.2006.MAR.G26.8

Abstract: G26.00008 : A Device of Tracking a Single Nanometer-Sized Particle in 3D with Nanometer Resolution and Millisecond Response Time.

10:12 AM–10:24 AM

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  Hu Cang
    (Lawrence Berkeley National Lab.)

  C. Shan Xu
  Daniel Montiel
  Haw Yang
    (University of California Berkeley)

We demonstrate a microscope system based on a confocal setup that can `track' a moving particle in three dimensions (3D) and `trap' it at a target position with nanometer spatial and millisecond time resolution. This is achieved by moving a 3D piezoelectric translation stage controlled by a feedback circuit to `cancel' the displacement of the particle. By keeping the target particle inside the confocal volume, it is now possible to perform other spectroscopic experiments on the particle simultaneously for a long time while the particle is moving freely in solutions. Our device overcomes the difficulty of single molecule spectroscopy (SMS) experiment on free moving samples.

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