Bulletin of the American Physical Society
2005 APS March Meeting
Monday–Friday, March 21–25, 2005; Los Angeles, CA
Session H7: Nanomechanical Biosensors |
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Sponsoring Units: DBP Chair: Thomas Thundat, Oak Ridge National Laboratory Room: LACC 408B |
Tuesday, March 22, 2005 8:00AM - 8:36AM |
H7.00001: Cantilever Arrays for Multiplexed Analysis of Chemical and Biomolecular Reactions Invited Speaker: Cantilever beams have been used to mechanically detect and quantitatively analyze multiple reactions in gaseous and aqueous media. The reaction- induced deflection of a cantilever beam reflects the interplay between strain energy increase of the beam and the free energy reduction of a reaction, providing an ideal tool for investigating the connection between mechanics and chemistry of reactions. Since free energy reduction is common for all reactions, the cantilever array forms a universal platform for label-free detection of various reactions. While the science underlying chemical-to-mechanical free energy transduction is still being understood, the technological potential can be truly realized if multiple reactions can be detected simultaneously. This talk will focus on both the scientific understanding as well as the technological progress in the development of cantilever-based analysis of chemical and biomolecular reactions. [Preview Abstract] |
Tuesday, March 22, 2005 8:36AM - 9:12AM |
H7.00002: Chemical Specificity in Nanomechanical Sensors Invited Speaker: The chemical specificity can be achieved by selection of appropriate receptors that recognize the target analyte and the recognition event can be converted into a measurable nanomechanical signal. The receptors are categorized as chemical receptors and bioreceptors. So far, the chemical receptors used for nanomechanical sensors include crown ethers, calixarenes, specific functional groups, etc. Bioreceptors include enzyme, antibody, microorganism, cell, etc. Receptor immobilization methods applied to nanomechanical sensors include self-assembled monolayers, layer- by-layer technique, polymer doping approach, and conjugation chemistries. In this presentation, the author will summarize the receptors and immobilization approaches reported for nanomechanical sensors and interpret the mechanism and dynamic relationship of recognition induced nanomechanical motions. [Preview Abstract] |
Tuesday, March 22, 2005 9:12AM - 9:48AM |
H7.00003: A Novel Electronic Transduction Scheme with MOSFET-Embedded Microcantilevers for Bio-Chem Sensing Invited Speaker: Microcantilever-based molecular sensing is rapidly emerging as a label-free high-sensitivity platform for molecular binding studies. However, the current schemes to detect cantilever bending have several shortcomings, which make it difficult for multiplexing and wide deployment. As an alternative, we present a novel approach for detecting subtle bending of microcantilevers based on drain current change in classic MOSFET embedded underneath the microcantilevers. Our approach relies on differential drain current signal between reference and analyte microcantilevers, both of which have embedded field-effect-transistors, whose drain current characteristic are sensitive to microcantilever bending. Microcantilevers bending, as small as few nanometers, can be readily registered in this approach. Full-scale simulation and optimization of the microcantilevers have allowed us to position the MOSFET at the appropriate location to enhance the sensitivity and reduce the various noise components to a minimum. The presentation will cover the basic philosophy behind MOSFET-embedded microcantilevers, and demonstrate its effectiveness with several examples of biomolecular binding events, including: DNA hybridization, protein-protein binding, and antigen-antibody binding. It will be argued that MOSFET-embedded microcantilevers offer a unique approach of electronic transduction for molecular binding event, and enjoy numerous technical advantages for wide-spread deployment and ready for massively parallel diagnostic platform. [Preview Abstract] |
Tuesday, March 22, 2005 9:48AM - 10:24AM |
H7.00004: Suspended microchannel resonators for biomolecular detection Invited Speaker: Our research focuses on using silicon microfabrication to develop quantitative, high throughput and real-time techniques for measuring biomolecular interactions. Over the last two years, we have developed a new detection method where specific biomolecules adsorb to the walls of a suspended microchannel resonator and thereby lower its resonant frequency. Confining the fluid to the inside of the resonator significantly increases sensitivity by eliminating high damping and viscous drag. It also enables direct integration with conventional microfluidic systems and allows the resonator to be actuated by electrostatic forces. In this presentation, I will introduce the resonator, show recent progress towards achieving its fundamental limit of detection, and discuss applications for real-time biomolecular detection. [Preview Abstract] |
Tuesday, March 22, 2005 10:24AM - 11:00AM |
H7.00005: Nanomechanics and Electronic Detection in Biosensing Invited Speaker: Integration of microscale and nanoscale systems together offer ways to increase detection sensitivity and specificity as well as enhancing the processing speed and analysis of chemical and/or biological agents. Implementation of a multifunctional detection system for both chemical and biological agents will require leveraging the integration of nanoscale components (e.g., carbon nanotubes). Transduction of a specific chemical/biological reaction into a `real world' ($i.e$., electrical, mechanical or optical) signal is needed before it can be relayed via microelectronics to the `outside world.' Single walled carbon nanotubes (SWNTs) are nearly ideal, one-dimensional nanostructures and exhibit other unique properties that may be useful in novel nanoelectronics and nanomechanics applications. Here, the fabrication and electrical properties of SWNT devices as a field effect transistor (FETs) will be presented. We have used these SWNT-FET devices as highly sensitive nano-biosensors for the \textit{in-situ} detection of the protein molecules. Results of these experiments will be used in elucidating the role of charge transfer and adsorption on the transport properties. Finally, the future prospects of nanotube devices combining electronics and mechanical detection will be discussed. [Preview Abstract] |
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