Bulletin of the American Physical Society
2005 APS March Meeting
Monday–Friday, March 21–25, 2005; Los Angeles, CA
Session D6: The Facts of Life: Data-Driven Approaches To Systems Biology |
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Sponsoring Units: DBP DCOMP Chair: Chris Wiggins, Columbia University Room: LACC 502A |
Monday, March 21, 2005 2:30PM - 3:06PM |
D6.00001: A Predictive Approach to Network Reverse-Engineering Invited Speaker: A central challenge of systems biology is the ``reverse engineering" of transcriptional networks: inferring which genes exert regulatory control over which other genes. Attempting such inference at the genomic scale has only recently become feasible, via data-intensive biological innovations such as DNA microrrays (``DNA chips") and the sequencing of whole genomes. In this talk we present a predictive approach to network reverse-engineering, in which we integrate DNA chip data and sequence data to build a model of the transcriptional network of the yeast S. cerevisiae capable of predicting the response of genes in unseen experiments. The technique can also be used to extract ``motifs,'' sequence elements which act as binding sites for regulatory proteins. We validate by a number of approaches and present comparison of theoretical prediction vs. experimental data, along with biological interpretations of the resulting model. En route, we will illustrate some basic notions in statistical learning theory (fitting vs. over-fitting; cross- validation; assessing statistical significance), highlighting ways in which physicists can make a unique contribution in data- driven approaches to reverse engineering. [Preview Abstract] |
Monday, March 21, 2005 3:06PM - 3:42PM |
D6.00002: Discovering modularity of biological and engineered networks Invited Speaker: |
Monday, March 21, 2005 3:42PM - 4:18PM |
D6.00003: Decoding the genome- computational identification of microRNA targets Invited Speaker: |
Monday, March 21, 2005 4:18PM - 4:54PM |
D6.00004: High Throughput Microscopy for Cell Biology Invited Speaker: This abstract has not been submitted yet. [Preview Abstract] |
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