Bulletin of the American Physical Society
70th Annual Meeting of the APS Division of Fluid Dynamics
Volume 62, Number 14
Sunday–Tuesday, November 19–21, 2017; Denver, Colorado
Session E4: Respiratory: Surfactant, Bifurcating Fows, and Airway Wall StressBio Fluids: Internal
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Chair: Julien Favier, University Aix-Marseille Room: 404 |
Sunday, November 19, 2017 4:55PM - 5:08PM |
E4.00001: Effects of surfactant on propagation and rupture of a liquid plug in a tube Nasuh Yildiran, Hideki Fujioka, James Grotberg, Metin Muradoglu Surfactant-laden liquid plug propagation and rupture occurring in lower lung airways are studied computationally using a front-tracking method. The plug is driven by an applied constant pressure in a rigid axisymmetric tube whose inner surface is coated by a thin liquid film. The evolution equations of the interfacial and bulk surfactant concentrations coupled with the incompressible Navier-Stokes equations are solved in the front-tracking framework. Available experimental data for surfactant Survanta are used to relate surface tension coefficient to surfactant concentration at the interface. The numerical method is first validated for a surfactant-free case and the results are found to be in good agreement with the earlier simulations of Fujioka et al. (2008) and Hassan et al. (2011). Then extensive simulations are performed to investigate the effects of surfactant on the mechanical stresses that could be injurious to epithelial cells such as pressure and shear stress and their gradients. It is found that the mechanical stresses are significantly reduced with the introduction of surfactants. Simulations are also performed to examine the effects of viscoelasticity contained in the liquid plug and some preliminary results are presented. [Preview Abstract] |
Sunday, November 19, 2017 5:08PM - 5:21PM |
E4.00002: 3D CFD Simulation of Plug Dynamics and Splitting through a Bifurcating Airway Model Cory Hoi, Mehdi Raessi Respiratory distress syndrome (RDS) occurs because of pulmonary surfactant insufficiency in the lungs of preterm infants. The common medical procedure to treat RDS, called surfactant respiratory therapy (SRT), involves instilling liquid surfactant plugs into the pulmonary airways. SRT's effectiveness highly depends on the ability to deliver surfactant through the complex branching airway network. Experimental and computational efforts have been made to understand complex fluid dynamics of liquid plug motion through the lung airways in order to increase SRT's response rate. However, previous computational work used 2D airway model geometries and studied plug dynamics of a pre-split plug. In this work, we present CFD simulations of surfactant plug motion through a 3D bifurcating airway model. In our 3D y-tube geometry representing the lung airways, we are not limited by 2D or pre-split plug assumptions. The airway walls are covered with a pre-existing liquid film. Using a passive scalar marking the surfactant plug, the plug splitting and surfactant film deposition is studied under various airway orientations. Exploring the splitting process and liquid distribution in a 3D geometry will advance our understanding of surfactant delivery and will increase the effectiveness of SRT. [Preview Abstract] |
Sunday, November 19, 2017 5:21PM - 5:34PM |
E4.00003: Respiratory Mechanics and Gas Exchange: The Effect of Surfactants. Abdulrahman Jbaily, Andrew J. Szeri The purpose of the lung is to exchange gases, primarily oxygen and carbon dioxide, between the atmosphere and the circulatory system. To enable this exchange, the airways in the lungs terminate in some 300 million alveoli that provide adequate surface area for transport. During breathing, work must be done to stretch various tissues to accommodate a greater volume of gas. Considerable work must also be done to expand the liquid lining (hypophase) that coats the interior surfaces of the alveoli. This is enabled by a surface active lipo-protein complex, known as pulmonary surfactant, that modifies the surface tension at the hypophase-air interface. Surfactants also serve as physical barriers that modify the rate of gas transfer across interfaces. We develop a mathematical model to study the action of pulmonary surfactant and its determinative contributions to breathing. The model is used to explore the influence of surfactants on alveolar mechanics and on gas exchange: it relates the work of respiration at the level of the alveolus to the gas exchange rate through the changing influence of pulmonary surfactant over the breathing cycle. This work is motivated by a need to develop improved surfactant replacement therapies to treat serious medical conditions. [Preview Abstract] |
Sunday, November 19, 2017 5:34PM - 5:47PM |
E4.00004: ABSTRACT WITHDRAWN |
Sunday, November 19, 2017 5:47PM - 6:00PM |
E4.00005: Effect of variation of geometric parameters on the flow within a synthetic models of lower human airways Andres Santiago Espinosa Moreno, Carlos Alberto Duque Daza The effects of variation of two geometric parameters, such as bifurcation angle and carina rounding radius, during the respiratory inhalation process, are studied numerically using two synthetic models of lower human airways. Laminar flow simulations were performed for six angles and three rounding radius, for 500, 1000, 1500 and 2000 for Reynolds numbers. Numerical results showed the existence of a direct relationship between the deformation of the velocity profiles (effect produced by the bifurcation) and the vortical structures observed through the secondary flow patterns. It is observed that the location of the vortices (and their related saddle point) is associated with the displacement of the velocity peak. On the other hand, increasing the angle and the rounding radius seems to bring about a growth of the pressure drop, which in turn displaces the distribution and peaks of the maximum shear stresses of the carina, that is, of the bifurcation point. Some physiological effects associated with the phenomena produced by these geometric variations are also discussed. [Preview Abstract] |
Sunday, November 19, 2017 6:00PM - 6:13PM |
E4.00006: Parametric Study of Wall Shear Stress in Idealized Avian Airways Michael S Farnsworth, Tobias Riede, Scott L Thomson Because wall shear stress (WSS) affects cell response, WSS patterns in avian respiratory airways may be related to the origin of the syrinx and corresponding voice-producing tissue structures (e.g., membranes or vocal folds) in birds. To explore possible linkages between WSS patterns and the locations of avian voice-producing structures, a computational model of flow through an idealized portion of the avian respiratory airway, including trachea and primary bronchi sections, has been developed. The flow is governed by the Navier-Stokes equations, with velocity boundary conditions derived from pressure-flow data in an adult zebra finch during quiet respiration. Geometric parameters such as tracheal/bronchial diameter and length, as well as bronchial branching angle, are parametrically varied based on data for different avian species. Simulation results predict elevated WSS in the vicinity of the tracheobronchial juncture, the location at which voice-producing tissues are found in avian species. In this presentation, the model will be described and spatial distributions of WSS during inspiration and expiration will be presented and compared for different geometric configurations and respiration rates and waveforms. [Preview Abstract] |
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