Bulletin of the American Physical Society
64th Annual Meeting of the APS Division of Fluid Dynamics
Volume 56, Number 18
Sunday–Tuesday, November 20–22, 2011; Baltimore, Maryland
Session H13: Multiphase Flow IV: Numerical I
10:30 AM–12:40 PM,
Monday, November 21, 2011
Chair: Olivier Desjardins, Cornell University
Abstract ID: BAPS.2011.DFD.H13.5
Abstract: H13.00005 : Multiscale modeling of blood-plasma separation in bifurcations*
11:22 AM–11:35 AM
Preview Abstract Abstract
(Johns Hopkins University)
Motion of a suspension of red blood cells (RBCs) flowing in a Y-shaped bifurcating microfluidic channel is investigated using a low-dimensional RBC validated 3D model based on dissipative particle dynamics. No-slip wall boundary and adaptive boundary conditions were implemented to model hydrodynamic flow within a specific wall structure of diverging microfluidic channels. Plasma skimming and the all-or-nothing phenomenon of RBCs in a bifurcating microfluidic channel have been investigated in our simulations, including the size of cell-free layer on the daughter channels. The results show that the flowrate ratio of the daughter channels and the feed hematocrit level have considerable influence on blood-plasma separation. Compared with the particle recovery efficiencies of healthy RBCs, malaria-infected RBCs ($i$RBCs) have a tendency to travel into the low flowrate daughter channels because of the increased stiffness of $i$RBCs. The simulation results are consistent with previous experimental results and theoretical predictions.
*This work was suporrted by the National Institute of Health (NIH), Grant R01Hl094270 and the National Science Foundation (NSF) Grant CBET-0852948.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.DFD.H13.5
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