2005 58th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 20–22, 2005;
Chicago, IL
Session FQ: Japan-US Minisymposium on Bio-Fluid Dynamics
8:00 AM–10:10 AM,
Monday, November 21, 2005
Hilton Chicago
Room: Stevens 2
Chair: Stanley Berger
Abstract ID: BAPS.2005.DFD.FQ.5
Abstract: FQ.00005 : \textbf{Hemodynamic Intervention of Cerebral Aneurysms}
9:44 AM–10:10 AM
Preview Abstract
Abstract
Author:
Hui Meng
(University at Buffalo and Toshiba Stroke Research Center)
Cerebral aneurysm is a pathological vascular response to hemodynamic
stimuli. Endovascular treatment of cerebral aneurysms essentially alters the
blood flow to stop them from continued growth and eventual rupture. Compared
to surgical clipping, endovascular methods are minimally invasive and hence
rapidly gaining popularity. However, they are not always effective with
risks of aneurysm regrowth and various complications. We aim at developing a
Virtual Intervention (VI) platform that allows: patient-specific flow
calculation and risk prediction as well as recommendation of tailored
intervention based on quantitative analysis.~ This is a lofty goal requiring
advancement in three areas of research: (1). Advancement of image-based CFD;
(2) Understanding the biological/pathological responses of tissue to
hemodynamic factors in the context of cerebral aneurysms; and (3) Capability
of designing and testing patient-specific endovascular devices. We have
established CFD methodologies based on anatomical geometry obtained from 3D
angiographic or CT images. To study the effect of hemodynamics on aneurysm
development, we have created a canine model of a vascular bifurcation
anastomosis to provide the hemodynamic environment similar to those in CA.
Vascular remodeling was studied using histology and compared against the
flow fields obtained from CFD. It was found that an intimal pad, similar to
those frequently seen clinically, developed at the flow impingement site,
bordering with an area of `groove' characteristic of an early stage of
aneurysm, where the micro environment exhibits an elevated wall shear
stresses. To further address the molecular mechanisms of the flow-mediated
aneurysm pathology, we are also developing in vitro cell culture systems to
complement the in vivo study. Our current effort in endovascular device
development focuses on novel stents that alters the aneurysmal flow to
promote thrombotic occlusion as well as favorable remodeling. Realization of
an effective VI platform requires a strong multi-disciplinary team of
engineers, biologists and clinicians.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2005.DFD.FQ.5